RESUMO
The objective of this study was to investigate the effect of hypothermia on the blood-brain barrier (BBB) disruption caused by traumatic brain injury (TBI) in chronically ethanol-treated rats. BBB permeability was measured using Evans blue (EB) dye. Arterial blood pressure levels of animals in hypothermic groups decreased significantly. The EB dye extravasation into the brain significantly increased in hypothermia and at 6 and 24 h after TBI. In ethanol-treated rats that were subjected to TBI, hypothermia led to a significant decrease in EB dye content in the brain at 24 h but not at 6 h after TBI when compared with TBI alone.
Assuntos
Transtornos do Sistema Nervoso Induzidos por Álcool/fisiopatologia , Barreira Hematoencefálica/fisiopatologia , Lesões Encefálicas/fisiopatologia , Etanol/efeitos adversos , Hipotermia/fisiopatologia , Acidentes por Quedas/estatística & dados numéricos , Transtornos do Sistema Nervoso Induzidos por Álcool/complicações , Alcoolismo/complicações , Alcoolismo/fisiopatologia , Animais , Pressão Sanguínea/fisiologia , Barreira Hematoencefálica/efeitos dos fármacos , Peso Corporal/fisiologia , Encéfalo/irrigação sanguínea , Encéfalo/patologia , Encéfalo/fisiopatologia , Lesões Encefálicas/complicações , Depressores do Sistema Nervoso Central/efeitos adversos , Doença Crônica , Modelos Animais de Doenças , Azul Evans , Hipotermia/complicações , Hipotermia Induzida , Masculino , Ratos , Ratos Wistar , Fatores de RiscoRESUMO
Determination of the manner of death in the case of intra- and perioral firearm wounds can be difficult especially if death scene investigation is unclear and inadequate. In this study, we investigated some characteristics of these firearm wounds which were autopsied in Istanbul. During the 5-year period from 1991 through 1995, there were 15 intra- and perioral firearm fatalities investigated. In all the cases, only one shot was fired into the mouth. They constituted 1% of all the firearm fatalities. The mean age of the victims was 27 years and males constituted 73.3% of the victims. Most of the wounds were caused by handguns. Homicides accounted for 53.3% of these deaths. Three of 15 cases could not be identified as intraoral firearm wounds by general practitioners during the scene investigations.
